Ki-67 EXPRESSION STATUS IN INVASIVE CARCINOMAS OF BREAST: A CO-RELATION WITH CLINICO-PATHOLOGIC AND PROGNOSTIC PARAMETERS

Sara Sadiq; Uzma Rihan; Bushra Parveen; Javaria Ahsan; Afia Shafiq; Sidra Shaukat

doi:10.52229/ajahs.v7i2.1849

Sara Sadiq Post-graduate Resident, CMH Lahore.
Uzma Rihan Professor CMH, Lahore.
Bushra Parveen Assistant Professor CMH, Lahore.
Javaria Ahsan Assistant Professor, CMH Lahore.
Afia Shafiq Associate Professor CMH Lahore
Sidra Shaukat Post-graduate Resident CMH Lahore.

DOI: https://doi.org/10.52229/ajahs.v7i2.1849

Abstract

BACKGROUND: The most common form of cancer in women around the globe is breast carcinoma with the highest mortality rate reported. Statistics reveal that it has around 1.7 million newly diagnosed cases every year. Risk factors identified in development of breast carcinomas include genetic predisposition, exposure to ionizing radiation and un-opposed prolonged estrogen secretion.

OBJECTIVE: To determine the Ki-67 expression status in invasive carcinomas of breast and its co-relation with clinico-pathologic and prognostic parameters.

METHODOLOGY: An aggregate of 32 mastectomy specimens of invasive ductal carcinomas comprised the study specimen. Information was collected on age, tumour size, tumour grade and nodal involvement. Immunohistochemistry study for estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor 2 (Her2) and Ki-67 was performed employing DAKO envision Kit.

RESULTS: Patient age varied from 28-63 years alongside a mean of 47±10.7 years. Age, tumour grade, ER status, and lymph node involvement did not show significant correlation with Ki-67 index. Tumour size was the only clinic-pathologic factor depicting a positive correlation with Ki-67. Whereas HER2 and PgR show a weak negative correlation with Ki-67 index. Comparing Ki-67 levels in various groups based on presence or absence show a mean level of 54.5 ±26.5% and 46.1 ±24.3% in Her2 negative and positive groups respectively (p=0.4), 52.36±30.9% and 51.9±16.8% in PgR negative and positive groups (p= 0.001) and 48.8±29.5% and 56.4±20.3% in ER negative and positive groups respectively (p=0.006).

CONCLUSION: Evaluation of tissue Ki-67 expression can prove to be a purposeful prognostic aid besides other prognostic factors and markers of tumour biology including estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor 2 (Her2).

KEYWORDS: Breast carcinoma, invasive ductal carcinoma, estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth receptor (Her2), Ki-67, Lymph node.