Assessment of Renal Function Test (RFT), BUN/Cr Ratio and their interaction with Disease Severity among COVID-19 Patients in a Tertiary Care Hospital

Madiha Mumtaz; Fatima Khurshid; Samiullah Mumtaz

doi:10.52229/ajahs.v7i2.1689

Madiha Mumtaz Shalamar Medical and Dental College, Lahore, Pakistan
Fatima Khurshid Shalamar School of Allied Health Sciences, Lahore, Pakistan
Samiullah Mumtaz Shalamar Medical and Dental College, Lahore, Pakistan

DOI: https://doi.org/10.52229/ajahs.v7i2.1689

Abstract

Background: Most regularly affected organs via severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the lungs, nonetheless there is also interaction among kidneys and COVID-19. SARS-CoV-2 infection not only leads to a new kidney injury but then also increases the regimen difficulties, in addition, increases the death rate. To decrease mortality, diagnosis and also the regimen therapy of SARS-CoV-2 must be accompanied by close monitoring of renal complications.

Objectives: This study was intended to assess if the renal function was linked with the possibility of severe infection or mortality in COVID-19 patients from usual blood parameters, particularly the blood urea nitrogen/ creatinine (BUN)/(Cr) ratio.

Methodology: A sum of 88 COVID-19 patients were studied at Shalamar Teaching Hospital. The patients were classified into three groups in consonance with the severity of the disease, (severe, moderate, and mild). Demographic data, medical information, and routine renal profiles were studied.

Results: Out of 88 patients, 46 males and 42 were females. The most noteworthy number of patients 37.9% was in the mild classification. Frequent symptoms were fever 70.1%, cough 43.7%, and myalgias 41.3% Underlying comorbidities were present in 43.7% of patients. Serum Urea levels were elevated in 33.0% of patients and serum creatinine levels were elevated in 31.0% of patients. eGFR was lower in 62.5% of patients. One-way ANOVA shows significant results in the case of urea, BUN/creatinine ratio, and eGFR. Blood urea levels and creatinine levels were found pointedly higher in individuals who died with p-values of 0.001 and 0.014 correspondingly.

Conclusion: COVID-19 affects the kidneys and might cause acute kidney injury (AKI). The BUN and albumin levels were viewed as dependable indicators of death in infected individuals. The eGFR also has effects on consequences related to COVID-19.

Keywords: COVID, complications, biomarker, mortality.