Frequency and antibiotics susceptibility pattern of Pseudomonas Aeruginosa isolated from various clinical specimens at Shalamar Hospital Laboratory

Frequency and antibiotics susceptibility pattern of Pseudomonas Aeruginosa in various isolates

Abstract

Background: Pseudomonas is a strict aerobic gram-negative bacillus. It exists naturally in the environment and is also associated with human infections. In the hospital environment, this microorganism is prevalent and can infect the patient through various sources e.g. contaminated instruments like ventilators, and catheters. Due to its high rate of resistance to available anti-pseudomonas antimicrobial agents it has been considered as one of the most challenging pathogens worldwide. Objective: This study was aimed to find out the frequency and antibiotic susceptibility pattern of Pseudomonas aeruginosa isolated from different clinical specimens. Methods: This was a descriptive study carried out in the Microbiology Laboratory Pathology Department Shalamar Teaching Hospital Lahore. The data of all the samples showed pure growth of Pseudomonas aeruginosa in Shalamar Hospital Laboratory from 1st January 2020 to 31st December 2020 was included. Results: Of 1387 positive cultures, 73 (5.3%) isolates were reported as P. aeruginosa. Majority of the isolates 52.1% were recovered from wound and pus swabs. The frequencies of antibiotic sensitivities against commonly used antibiotics were: Amikacin=75.3%, Ceftazidime=54.8%, Ciprofloxacin=61.6%, Colistin=86.3%, Gentamicin=61.6%, Imipenem=82.2%, Meropenem=84.9%, Piperacillin/Tazobactam=45.2%. Conclusion: According to this study Colistin and Meropenem are the most effective drugs that can be used for the treatment of P. aeruginosa infections in our hospital setting.

Key words: Antibiotic susceptibility, Colistin, Frequency, Pseudomonas aeruginosa